In this episode, hosts Emma Sullivan and David Park explore how vitamin A deficiency disrupts the retinoid signaling pathway that maintains your skin, gut lining, and immune function—and why adequate dietary intake alone isn't always enough as we age. They break down the real biology behind "barrier breakdown," explain why topical retinoids and systemic vitamin A status work through different mechanisms, and offer practical, evidence-based strategies for supporting regeneration without falling into supplement overcorrection. Listeners will understand why chronic low-grade inflammation and slow healing often trace back to dysregulated retinoid signaling rather than diet alone.
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