How is T-DXd changing the treatment landscape for HER2-positive breast cancer?


Drs. Ruta Rao and Irene Kang discuss the evolving role of trastuzumab deruxtecan (T-DXd) across HER2-positive breast cancer, from first-line metastatic disease to neoadjuvant and adjuvant treatment.

They examine data from DESTINY-Breast09, DESTINY-Breast05, and DESTINY-Breast11, along with emerging maintenance strategies from PATINA and HER2CLIMB-05. The conversation also explores how these findings are influencing treatment selection, duration, sequencing, toxicity management, and individualized patient care.


Topics discussed:

  • How DESTINY-Breast09 is changing first-line treatment for metastatic HER2-positive breast cancer
  • T-DXd plus pertuzumab versus the traditional THP approach
  • Complete response, deep partial response, and how long to continue T-DXd plus pertuzumab
  • When THP followed by maintenance therapy may still be considered
  • Managing T-DXd-associated nausea, ILD/pneumonitis, and fatigue
  • Screening, monitoring, and rechallenge considerations for ILD
  • PATINA and HER2CLIMB-05 maintenance strategies
  • How first-line T-DXd may affect subsequent treatment sequencing
  • DESTINY-Breast05 and the role of adjuvant T-DXd in patients with residual disease
  • DESTINY-Breast11 and incorporating T-DXd into neoadjuvant therapy
  • Selecting patients for neoadjuvant versus adjuvant T-DXd
  • Treatment considerations when residual disease remains after neoadjuvant T-DXd
  • The potential impact of T-DXd on CNS recurrence and future HER2-positive treatment strategies


▶️ Watch the full CHM Conversation for expert perspectives on translating evolving HER2-positive breast cancer evidence into clinical practice.


#RutaRao #IreneKang #CHMConversations #HER2PositiveBreastCancer #BreastCancer #TDXd #TrastuzumabDeruxtecan #DESTINYBreast09 #DESTINYBreast05 #DESTINYBreast11 #CommunityHealthMedia–


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