With more targeted therapies available for CLL, how are clinicians navigating the growing number of first-line treatment options?
Drs. Kerry Rogers, William Wierda, and Catherine Coombs discuss the evolving CLL treatment landscape, including fixed-duration versus continuous therapy, BTK- and BCL-2 inhibitor–based approaches, and how disease biology, comorbidities, treatment logistics, and patient preferences can guide treatment selection.
Topics discussed:
Fixed-duration vs. continuous first-line therapy
Choosing among BTK inhibitor-based strategies
Acalabrutinib + venetoclax and venetoclax + obinutuzumab
Treatment considerations for TP53 mutation and del(17p)
The emerging investigational role of pirtobrutinib in frontline CLL
Key testing to inform first-line CLL treatment decisions
Sequencing therapy and the role of BTK inhibitors after frontline venetoclax-based therapy or chemoimmunotherapy
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#CHMConversations #KerryRogers #WilliamWierda #CatherineCoombs #CLL #ChronicLymphocyticLeukemia #BTKInhibitors #Venetoclax #Hematology #CommunityHealthMedia
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