For more than a decade, THP—established by the landmark CLEOPATRA trial— defined the first-line standard for HER2-positive metastatic breast cancer. Now, DESTINY-Breast09 is changing the conversation.
In this CHM Conversation, Dr. Sonya Reid and Dr. Shruti Singh discuss the evolving first-line treatment landscape and how trastuzumab deruxtecan (T-DXd) plus pertuzumab is reshaping clinical decision-making for patients with HER2-positive metastatic breast cancer.
They explore which patients may benefit most from a T-DXd-based approach, how prior T-DXd exposure in early-stage disease could influence treatment at metastatic recurrence, and where THP may still have a role. The conversation also examines practical considerations around toxicity management, maintenance strategies in HER2+ disease, sequencing, and individualized treatment selection.
Topics discussed:
How CLEOPATRA and THP established the first-line standard
DESTINY-Breast09 and T-DXd plus pertuzumab
Treatment considerations for high-risk and HR+/HER2+ disease
Brain metastases and high visceral disease burden
How prior neoadjuvant or adjuvant T-DXd may influence treatment
Managing nausea, fatigue, and ILD with T-DXd
Dose modifications and maintaining quality of life with T-DXd
PATINA and HER2CLIMB-05 maintenance approaches
Treatment sequencing after first-line T-DXd plus pertuzumab
▶️ Watch the full conversation and subscribe to Community Health Media for more expert perspectives on the latest research and evolving approaches in cancer care.
#CHMConversations #SonyaReid #ShrutiSingh #HER2Positive #MetastaticBreastCancer #DESTINYBreast09 #TDXd #TrastuzumabDeruxtecan #BreastCancer #BreastOncology #MedicalOncology #CommunityHealthMedia
–
Thanks for watching!
Our podcasts are also available on:
• Spotify - https://spotf.fi/chm-podcast
• Amazon Music - https://amazn.so/chm-podcast
• Apple Podcast - https://podcasts.apple.com/us/podcast...
• Castbox - https://castbox.fm/vh/6735434
• Goodpods - https://goodpods.com/profile/chm-111066
• iHeartRadio - https://iheart.com/podcast/291542082
• Pocket Casts - https://pca.st/3ncdh11o
–
Community Health Media (CHM) is your full service healthcare communications partner, combining our production expertise with targeted multi-channel campaigns. We connect companies and healthcare brands with key opinion leaders, patients, and consumers through compelling content and live experiences.
We’re an integrated marketing company that produces world-class content and curated peer to peer live experiences.
We specialize in:
• Peer to peer interviews, panels & round-tables
• Curated live events & conferences
• Professional in-depth content & research updates
• Interactive learning modules & webinars
• Live & on-demand webcasts & podcasts
Learn more about us here - https://communityhealth.media
