How is the rapidly changing treatment landscape reshaping second-line ER-positive, HER2-negative metastatic breast cancer care?
In this Special CHM Conversation, Dr. Seth Wander and Dr. Paolo Tarantino discuss the growing number of endocrine therapy options and how clinicians can navigate increasingly complex treatment decisions.
They explore what the newly approved combination of imlunestrant plus abemaciclib means for patients with ESR1 mutations, how ctDNA and molecular profiling guide treatment selection, and why sequencing next-generation endocrine therapies remains an open question as new options emerge.
Topics discussed:
- EMBER-3 and imlunestrant plus abemaciclib
- Treatment options for ESR1-mutated disease
- Single-agent vs combination endocrine therapy
- ctDNA and molecular profiling
- Biomarker-driven treatment selection
- Balancing efficacy and tolerability
- SERENA-6 and molecular progression
- Sequencing next-generation endocrine therapies
- Oral SERDs in the adjuvant and first-line settings
- Emerging doublet and triplet strategies
▶️ Watch this Special CHM Conversation for expert perspectives on navigating the evolving second-line treatment landscape in ER-positive, HER2-negative metastatic breast cancer.
#SethWander #PaoloTarantino #CHMConversations #ESR1 #EMBER3 #EndocrineTherapy #OralSERD #MetastaticBreastCancer #BreastCancer #CommunityHealthMedia
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