Research reveals that the mouse motor cortex is systematically organized into sixteen distinct modules that align along two spatial axes. These projection-defined modules exhibit coordinated patterns of cell-type composition and corticocortical connectivity, dividing the region into primary and secondary domains. Furthermore, specific subcortical output targets integrate sensory and motor information through tightly structured convergence and divergence rules. This comprehensive anatomical framework establishes fundamental principles for how neuronal networks within the motor cortex coordinate movement and process information.
References:
Falasconi A, Kanodia H, Lusk N, et al. Projection-defined modules reveal mouse motor cortex architecture[J]. Cell, 2026.
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