Rosie O’Donnell reveals her dramatic weight loss journey with Mounjaro, shedding 65 pounds in three years after initially panicking when she lost 12 pounds in just three weeks—mistaking it for illness. She criticized doctors for not explaining weight loss as a side effect, and shared how the drug’s appetite suppression even fooled her into thinking she was stressed. Now thriving at 64, she champions the drug’s potential to help others with obesity, calling its high cost and limited access a “sin,” while balancing her dosage and preparing for a busy schedule including a one-woman show and a Jimmy Kimmel Live guest spot.
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