The Giants have a chance to improve to 4-1-1 against a struggling New Orleans Saints team, and Jameis Winston gets to face his former franchise. But injuries to New York's offensive line and pass rush, combined with ongoing ball-security concerns, could turn an expected Giants victory into another frustrating Sunday.

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Can Jameis Winston lead the New York Giants past his former team in Week 6?

The Giants have favorable matchups against New Orleans' struggling defense, but protecting Winston, avoiding turnovers, and limiting Tyler Shough will be essential to securing a victory.

Drew previews the New York Giants vs New Orleans Saints matchup with New York sitting at 3-1-1 and leading the NFC East, while New Orleans enters at 1-4. Despite that difference, the Saints are favored on the road.

Can the Giants finally get their running game going?

New Orleans is allowing 148.8 rushing yards and 30.2 points per game. That creates an opportunity for Cam Skattebo, Tyrone Tracy Jr., and the Giants offense to establish the run and open up the passing game. But Skattebo's fumbling problems remain a concern, especially after the costly overtime turnover against Washington.

Jameis Winston's return against New Orleans adds another dimension to the game. Drew discusses Winston's previous years with the Saints, his leadership in New York, his developing chemistry with Malik Nabers and Isaiah Likely, and whether facing his former teammates could provide additional motivation.

Will injuries keep the Giants from taking advantage?

Andrew Thomas and Jermaine Eluemunor both missed Wednesday's practice, creating questions about the matchup against Chase Young and Carl Granderson. Abdul Carter's calf injury adds further uncertainty to a Giants pass rush already missing Brian Burns.

Drew examines whether Dennard Wilson's aggressive defense can exploit Tyler Shough's struggles against pressure, how Chris Olave and Alvin Kamara could threaten New York, and why the Giants cannot afford to underestimate an opponent with a poor record.

The episode also covers the latest New York Giants news, including the offensive line's rise to No. 17 in PFF's rankings, Bryan Hudson's play at center, and the addition of Josh Gesky to the practice squad.

Drew examines whether the Giants deserve more respect in the NFC East race and why the betting markets still favor Philadelphia and Dallas to win the division. John Harbaugh's defense of Kayvon Thibodeaux, Dominic Zvada's kicking mechanics, Cam Skattebo's ball-security issues, and the J.J. McCarthy quarterback package are also discussed.

The episode finishes with the biggest keys to Giants-Saints, the important matchups that could decide the outcome, and a quick Seattle Seahawks vs Denver Broncos Thursday Night Football prediction.

Are the Giants legitimate NFC East contenders, or are their close-game escapes hiding problems that could finally catch up to them?

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