The New York Giants have a chance to strengthen their lead in the NFC East, but injuries to Abdul Carter and both starting offensive tackles could threaten their 3-1-1 momentum. Can John Harbaugh's team overcome those losses and keep winning, or are the Giants running out of healthy answers before the Saints arrive?

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Can the Giants beat the Saints despite their growing injury concerns?

New York has home-field momentum and a defense capable of making life difficult for New Orleans, but missing key contributors could put additional pressure on Jameis Winston and the remaining roster.

Drew and Rob begin with the latest Giants injury concerns, including Abdul Carter, Jermaine Eluemunor, Andrew Thomas, Colton Hood and Tyler Nubin. With Brian Burns already out for the season, the availability of Carter becomes especially important to New York's pass rush.

Matt Nagy believes the Giants have identified ways to improve their running game, but are the actual problems the offensive line and the play calling rather than the running backs? The hosts also question why New York continues to use the J.J. McCarthy package while trying to win games with Winston.

Cam Skattebo's ball-security problems lead to another debate after the running back explains why he removed his wet gloves against Washington. Former Giants kicker Lawrence Tynes also provides an explanation of Dominic Zvada's missed kicks, identifying differences in plant-foot positioning that could be affecting his accuracy.

And then there's the Jaxson Dart trade proposal. Former NFL tackle Terron Armstead suggested a hypothetical deal sending Dart and two first-round picks for Justin Herbert. Drew and Rob have strong opinions about that idea, Herbert's record, and whether the Giants should even consider sacrificing that much for a veteran quarterback.

Could Week 6 create an even bigger opening for the Giants in the NFC East?

The conversation then moves across the NFL with 13 Week 6 game predictions, point spreads, totals and possible upsets.

We start with Saints–Giants and the important question of whether Winston can beat his former team. From there, it's Texans–Jaguars in London, Bears–Falcons, Ravens–Browns, Titans–Colts, and the other early matchups.

One of the biggest stories involves Philadelphia. Jalen Hurts has been ruled out against Carolina after doctors identified a superficial blood clot in his leg. With Tanner McKee taking over, the Eagles face an uncertain stretch that could affect the NFC East standings. The hosts discuss the potential implications for the Giants' upcoming meeting with Philadelphia, without a confirmed timetable for Hurts' return.

The picks continue with Panthers–Eagles, Buccaneers–Steelers, Cardinals–Rams, Chargers–Chiefs and Bills–Raiders, with disagreements over favorites, injuries and which teams deserve more respect.

Sunday Night Football brings another NFC East matchup as the Dallas Cowboys travel to Green Bay. Can Dallas keep pace with the Packers at Lambeau Field, or will Green Bay take advantage of the Cowboys' defensive problems?

We close with Commanders–49ers on Monday Night Football and what the outcome could mean for the division.

The Giants have put themselves in a position that few fans expected this early in the season. Now they need to prove that injuries, turnovers and an inconsistent running game won't stop them from building on that start.

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