Dr. Mike Hart welcomes Ksenia Petrushkina back for a wide-ranging conversation about using hormones, GLP-1 medications, and peptides more thoughtfully. They explore why lower, individualized doses of tirzepatide may improve tolerability, which blood markers should be monitored during treatment, and how progesterone may support sleep through its effects on GABA. They also discuss women's hormone replacement therapy, personalized testosterone dosing, TRT and fertility, thyroid treatment, low-dose naltrexone, and the difference between evidence-based peptide use and exaggerated online claims.
Ksenia Petrushkina is a clinician whose work focuses on hormone optimization, peptide therapy, metabolic health, and highly individualized treatment. Through comprehensive blood testing, symptom assessment, careful dose adjustments, and ongoing patient monitoring, she helps men and women better understand how hormones, medications, and peptides may affect their energy, sleep, inflammation, fertility, body composition, and long-term health. Her approach challenges standardized protocols and social-media biohacking trends, emphasizing personalized medicine, responsible prescribing, and evaluating one intervention at a time.
Quick Coherence Technique — HeartMath
https://help.heartmath.com/introduction/quick-coherence-technique/
The Levels of Ghrelin, Glucagon, Visfatin and GLP-1 Are Decreased in the Peritoneal Fluid of Women with Endometriosis — Aleksey M. Krasnyi et al.
https://pubmed.ncbi.nlm.nih.gov/36142272/
Women's Health Initiative — National Heart, Lung, and Blood Institute, National Institutes of Health
https://www.nhlbi.nih.gov/science/womens-health-initiative-whi
Facial Beauty Age Support Serum for Estrogen Deficiency — Quicksilver Scientific
https://www.quicksilverscientific.com/products/facial-beauty-serum
Peptides: The Science, Uses & Safety — Dr. Andrew Huberman and Dr. Abud Bakri
https://www.hubermanlab.com/episode/peptides-the-science-uses-and-safety-abud-bakri
Vladimir Khavinson Publications — Professor Vladimir Khavinson
https://khavinson.info/publications
Show Notes
00:00 Welcome to the Hart2Heart Podcast
00:57 GLP-1 Starting Doses
03:39 GLP-1 Anti Inflammation Aging
07:15 Motility Supplements Side Effects
09:02 Tirzepatide vs Semaglutide
11:46 Adrenal Fatigue Myth
13:23 Fatigue Bloodwork Checklist
16:16 TRT Hematocrit Sleep Apnea
19:01 Underrated Blood Tests
20:06 Womens HRT Basics
22:21 Testosterone for Women
25:19 Thyroid Treatment LDN NAD
29:31 Progesterone GABA Sleep
32:25 Progesterone for Men Debate
33:43 Testosterone Injection Frequency
36:05 TRT Dosing Frequency
36:45 Why TRT Stops Working
37:50 Creams vs Injections
39:08 Fertility and HCG
41:46 Peptides vs Pharma
44:17 HGH and Secretagogues
45:12 5-Amino-1-MQ Hype
48:15 Topical GHK-Cu Skincare
50:25 Injectable Copper Peptide Hair
52:26 BPC 157 and TB500
58:25 Thymosin Alpha 1 Immunity
01:01:13 Mitochondrial Peptides
01:03:20 Endo 205 and New Peptides
01:04:17 Kavinson and Epitalon
01:08:21 Wrap Up and Where to Find
The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance.
This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary.
Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being.
Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary
(Commissioner of the Food and Drug Administration (FDA) and high-profile names such as
Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen).
If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.
Connect with Dr. Mike Hart
Instagram: @drmikehart
Twitter: @drmikehart
Facebook: @drmikehart
