Dr. Tyler Panzner joins Dr. Mike Hart to explain how genetics, supplement combinations, and individual brain chemistry can influence anxiety, irritability, brain fog, and the persistent "monkey on your back" feeling. They examine why the MTHFR gene is scientifically valid but often overmarketed, and why methylated B vitamins, SAMe, creatine, phosphatidylcholine, and other methylation-related supplements may help some people while overstimulating others. The conversation also explores hidden "adrenaline trappers" such as quercetin, polyphenols, and greens powders; why NAC, glutathione, and high-dose antioxidants may cause unwanted effects; and how lithium orotate, melatonin, nicotine, methylene blue, omega-3s, collagen, mitochondrial enhancers, and DHT-lowering supplements can affect people differently. Dr. Panzner also discusses pharmacogenomics, SSRI response, supplement timing around exercise, the limitations of genetic testing, and the importance of combining DNA data with bloodwork, symptoms, medication history, and baseline nutrient status.
Dr. Tyler Panzner is a pharmacology and genetics expert whose work focuses on personalized supplementation, genetic testing, neurotransmitter pathways, and understanding why the same health intervention can affect people very differently. Through DNA analysis, laboratory review, supplement audits, and individualized coaching, he helps clients identify which biological pathways may need support and which commonly recommended supplements may be working against them. His approach challenges one-size-fits-all biohacking and emphasizes using genetics, bloodwork, symptoms, and personal response patterns to make more informed decisions about mental health, performance, and long-term wellness.
10X Methylation Genetic Test — Gary Brecka
https://shop.10xhealthsystem.com/products/10x-health-gene-testing-kit
Favorite Books, Supplements, Simple Technologies and More — Tim Ferriss
https://tim.blog/2018/02/02/the-tim-ferriss-show-transcripts-favorite-books-supplements-simple-technologies-and-more/
Lithium Deficiency and the Onset of Alzheimer's Disease — Liviu Aron et al.
https://www.nature.com/articles/s41586-025-09335-x
Curcumin and DHT — Andrew Huberman and Andy Galpin
https://ai.hubermanlab.com/clip?sids=chunk_56621
Omega-3 Fish Oil Supplements — Metagenics
https://www.metagenics.com/en-us/category/omega-3-fish-oil-supplements
Omega-3 Plus — Researched Nutritionals
https://www.researchednutritionals.com/product/omega-3-plus-double-strength-pure-soft-gels/
Brain Health From Morning to Night — Dr. Tommy Wood
https://open.spotify.com/episode/3OfDN5ZnJhme5CAHV3qZqI
BioPerine — Sabinsa Corporation
https://sabinsa.com/brand/bioperine
ZYN Nicotine Pouches — ZYN
https://www.zyn.com/ph/en/home.html
AG1 Greens Powder — AG1
https://drinkag1.com/
Toolkit for Sleep — Andrew Huberman
https://www.hubermanlab.com/newsletter/toolkit-for-sleep
23andMe DNA Testing — 23andMe
https://www.23andme.org/
ChatGPT — OpenAI
https://chatgpt.com/
Unlock Your Genetic Potential — Dr. Tyler Panzner
https://drtylerpanzner.com/
Dr. Tyler Panzner on Instagram — Tyler Panzner
https://www.instagram.com/drtylerpanzner/
Quieting an Overactive Mind Webinar — Tyler Panzner
https://overstimulated.drtylerpanzner.com/webinar-registration-page
Show Notes
00:00 Welcome to the Hart2Heart Podcast
00:47 MTHFR Hype vs Reality
02:14 Methylated Bs and Anxiety
03:48 Creatine Choline and SAMe
07:43 Beyond One Gene Test
11:14 Lithium Orotate Basics
15:18 Supplements That Backfire
17:36 Antioxidant Overload Effects
21:01 Melatonin Dose Debate
23:56 Antioxidants Around Workouts
26:48 Collagen What Actually Works
30:07 SSRIs and Genetic Fit
34:23 Herbal SSRI Alternatives
37:18 DHT Lowering Side Effects
41:54 Biohacking Marketing Hype
43:25 Fish Oil Mood Ratios
46:16 Oral Nicotine Tradeoffs
52:03 Methylene Blue Risks
54:46 Mitochondria Boosters Anxiety
57:13 Greens Powders Overstimulation
01:01:04 Magnesium Forms For Sleep
01:04:51 DNA Testing And ChatGPT
01:12:23 Genetics For Caffeine Sensitivity
01:16:23 Psychedelics And DNA
01:18:50 Coaching Logistics Wrap Up
The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance.
This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary.
Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being.
Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary
(Commissioner of the Food and Drug Administration (FDA) and high-profile names such as
Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen).
If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.
Connect with Dr. Mike Hart
Instagram: @drmikehart
Twitter: @drmikehart
Facebook: @drmikehart
