This episode explores how to use GLP-1 medications like semaglutide/Ozempic and tirzepatide/Mounjaro safely and effectively. Dr. Mike Hart and Dr. Christle Guevarra Do discuss once-weekly dosing, individualized titration, optimal dose selection, food noise, appetite suppression, and the risks of dosing mistakes with vials or gray-market peptides. They also cover why resistance training, protein, fiber, and realistic nutrition habits are essential for preserving muscle and maintaining results. The conversation expands into GLP-1 benefits beyond weight loss, including cardiovascular protection, inflammation, autoimmune flares, addiction-related behaviors, alcohol cravings, libido, menstrual cycles, PCOS, sleep apnea, and what to expect when stopping the medication.
Dr. Christle Guevarra Do is a physician focused on obesity medicine, GLP-1 education, weight management, and sustainable lifestyle change. Drawing from both her clinical experience and her own long-term use of GLP-1 medication, she helps patients understand how these medications fit into the bigger picture of long-term health. Her approach emphasizes individualized care, strength training, nutrition, behavior change, and realistic maintenance strategies rather than quick fixes. In this episode, she shares practical guidance for using GLP-1s responsibly while protecting muscle, managing hunger, and building habits that support lasting results.
Dr. Christle Guevarra Website
https://www.drchristle.com/
Dr. Christle's Free GLP-1 Guide
https://www.drchristle.com/glp1-guide
Dr. Christle Instagram
https://www.instagram.com/dr.christle/
Ozempic — semaglutide
https://www.ozempic.com/
Wegovy — semaglutide for weight management
https://www.wegovy.com/
Mounjaro — tirzepatide
https://mounjaro.lilly.com/
Zepbound — tirzepatide for weight management / sleep apnea
https://zepbound.lilly.com/
FDA: Concerns With Unapproved GLP-1 Drugs
https://www.fda.gov/drugs/drug-alerts-and-statements/fdas-concerns-unapproved-glp-1-drugs-used-weight-loss
Retatrutide Clinical Trial Info
https://clinicaltrials.gov/study/NCT05882045
Vyvanse — lisdexamfetamine
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=704e4378-ca83-445c-8b45-3cfa51c1ecad
Creatine — NIH Supplement Info
https://ods.od.nih.gov/factsheets/ExerciseAndAthleticPerformance-HealthProfessional/
Psyllium Husk / Fiber — MedlinePlus
https://medlineplus.gov/druginfo/meds/a601104.html
Berberine — NCCIH
https://www.nccih.nih.gov/health/berberine-and-weight-loss-what-you-need-to-know
Tesamorelin — MedlinePlus
https://medlineplus.gov/druginfo/meds/a611035.html
CJC-1295 — PubMed Research
https://pubmed.ncbi.nlm.nih.gov/16352683/
Ipamorelin — PubMed Research
https://pubmed.ncbi.nlm.nih.gov/9849822/
FDA: Peptides / Compounding Safety Concerns
https://www.fda.gov/drugs/human-drug-compounding/certain-bulk-drug-substances-use-compounding-may-present-significant-safety-risks
Oura Ring
https://ouraring.com/
White Claw
https://www.whiteclaw.com/
Show Notes
00:00 Welcome to the Hart2Heart Podcast
00:45 Weekly Dosing Debate
03:41 Starting Dose Basics
06:28 Pens vs Vials Safety
08:37 Finding Your Sweet Spot
11:01 Nighttime Binge Window
13:32 Lifestyle Work Still Matters
14:30 Benefits Beyond Weight
17:27 Libido and Low Calories
22:26 Alcohol Hits Different
24:59 Cancer Claims Reality Check
26:59 Strength Training Priority
29:06 Supplements and Creatine
29:38 Creatine Protein Fiber Basics
31:50 Berberine Pros and Cons
32:37 Peptides Sleep and Muscle
35:28 Too Lean for GLP-1
38:52 Cycles PCOS and Fertility
40:45 Food Noise vs Appetite
44:42 Staying On or Stopping
49:19 Heart Rate and HRV Concerns
51:38 Ozempic vs Mounjaro Choices
54:45 Sleep Apnea and Wrap Up
The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance.
This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary.
Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being.
Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary
(Commissioner of the Food and Drug Administration (FDA) and high-profile names such as
Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen).
If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.
Connect with Dr. Mike Hart
Instagram: @drmikehart
Twitter: @drmikehart
Facebook: @drmikehart
