Hart2Heart with Dr. Mike Hart
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#222 Peptides, Hormones, and Longevity: Safety, Skin Aging, NAD+, GLP-1s, and Mitochondrial Health with Dr. Ksenia

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Dr. Ksenia Petrushkina joins Dr. Mike Hart for a deep dive into regenerative medicine, peptides, hormones, IV therapies, and longevity. They discuss what conventional medicine and health influencers often get wrong about prevention-focused care, while exploring topics like NAD+, glutathione, GLP-1s, gut health, skin aging, mitochondrial health, BPC-157, TB-500, IGF-1, and peptide safety. Dr. Ksenia also shares why testing, inflammation, absorption, and overall health matter before using peptides or other optimization treatments.

Dr. Ksenia Petrushkina is a regenerative medicine practitioner based in Aventura, Florida, and part owner of Ideal Medical and Wellness. Her work focuses on hormones, peptides, IV therapies, stem cells, and longevity, with a background in biopharmaceutical science and cancer research. She brings a prevention-focused, mechanism-based perspective to patient care, especially around inflammation, gut health, metabolic function, peptide safety, and age-related optimization.

Dr. Ksenia Miami Instagram

https://www.instagram.com/dr.kseniamiami/](https://www.instagram.com/dr.kseniamiami/)

Ideal Medical and Wellness

https://idealmedwell.com/](https://idealmedwell.com/)

Tadalafil / Cialis

https://medlineplus.gov/druginfo/meds/a604008.html](https://medlineplus.gov/druginfo/meds/a604008.html)

PT-141 / Bremelanotide

[https://medlineplus.gov/druginfo/meds/a619054.html](https://medlineplus.gov/druginfo/meds/a619054.html)

GHK-Cu copper peptide

https://pmc.ncbi.nlm.nih.gov/articles/PMC6073405/](https://pmc.ncbi.nlm.nih.gov/articles/PMC6073405/)

Tretinoin / Retin-A

https://medlineplus.gov/druginfo/meds/a682437.html](https://medlineplus.gov/druginfo/meds/a682437.html)

NAD+

https://pmc.ncbi.nlm.nih.gov/articles/PMC7963035/](https://pmc.ncbi.nlm.nih.gov/articles/PMC7963035/)

Nicotinamide Riboside / NR

https://pmc.ncbi.nlm.nih.gov/articles/PMC6611812/](https://pmc.ncbi.nlm.nih.gov/articles/PMC6611812/)

Tru Niagen

[https://www.truniagen.com/](https://www.truniagen.com/)

Glutathione

https://pmc.ncbi.nlm.nih.gov/articles/PMC4684116/](https://pmc.ncbi.nlm.nih.gov/articles/PMC4684116/)

GLP-1 drugs

https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/fdas-concerns-unapproved-glp-1-drugs-used-weight-loss](https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/fdas-concerns-unapproved-glp-1-drugs-used-weight-loss)

Tirzepatide

https://medlineplus.gov/druginfo/meds/a622044.html](https://medlineplus.gov/druginfo/meds/a622044.html)

BPC-157

https://www.usada.org/spirit-of-sport/bpc-157-peptide-prohibited/](https://www.usada.org/spirit-of-sport/bpc-157-peptide-prohibited/)

TB-500 / Thymosin beta-4

https://pubmed.ncbi.nlm.nih.gov/22074294/](https://pubmed.ncbi.nlm.nih.gov/22074294/)

Melanotan II

https://dermnetnz.org/topics/melanotan-ii](https://dermnetnz.org/topics/melanotan-ii)

IGF-1 test

https://medlineplus.gov/lab-tests/igf-1-insulin-like-growth-factor-1-test/](https://medlineplus.gov/lab-tests/igf-1-insulin-like-growth-factor-1-test/)

Tesamorelin

https://medlineplus.gov/druginfo/meds/a611035.html](https://medlineplus.gov/druginfo/meds/a611035.html)

 

Thymosin Alpha-1

https://pmc.ncbi.nlm.nih.gov/articles/PMC7747025/](https://pmc.ncbi.nlm.nih.gov/articles/PMC7747025/)

SS-31 / Elamipretide

https://pmc.ncbi.nlm.nih.gov/articles/PMC11816484/](https://pmc.ncbi.nlm.nih.gov/articles/PMC11816484/)

Urolithin A

https://pubmed.ncbi.nlm.nih.gov/35050355/](https://pubmed.ncbi.nlm.nih.gov/35050355/)

Coenzyme Q10 / CoQ10

https://www.nccih.nih.gov/health/coenzyme-q10](https://www.nccih.nih.gov/health/coenzyme-q10)

Pancreatic enzymes

https://medlineplus.gov/druginfo/meds/a604035.html](https://medlineplus.gov/druginfo/meds/a604035.html)

Psyllium husk

https://medlineplus.gov/druginfo/meds/a601104.html](https://medlineplus.gov/druginfo/meds/a601104.html)

 

Show Notes

00:00 Welcome to the Hart2Heart Podcast

00:38 Preventive Medicine Debate

03:03 Low Dose Cialis Basics

05:03 Prostate Cancer Link

08:18 ED Alternatives PT-141

11:52 Skin Aging Essentials

12:19 GHK-Cu Dosing Risks

15:59 Copper Uglies Explained

19:47 NAD Boosting Options

24:33 NR Infusions Trend

27:38 Glutathione and Thyroid

31:58 Stopping Levothyroxine

33:34 Glutathione Precursors Limits

34:58 Gut Protocol NAD GLP1

35:59 Tirzepatide Microdosing Guide

38:18 Glutathione Injection Protocol

40:47 BPC 157 Cancer Myth

43:28 BPC TB500 Injury Cycles

45:13 Melanotan II Skin Risks

46:50 IGF1 Aging Tradeoffs

49:16 Safest GH Secretagogue

50:05 Underrated Thymosin Alpha

52:35 Mitochondria Peptides SS31

55:00 MITC and AMPK Hype

56:36 Urolithin A and CoQ10

01:00:36 GLP1 Supplements and Labs

01:02:39 Wrap Up and Where to Find

 

The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance.

This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary.

Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being.

Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary 

(Commissioner of the Food and Drug Administration (FDA) and high-profile names such as 

Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen).

If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.

Connect with Dr. Mike Hart

Instagram: @drmikehart
Twitter: @drmikehart
Facebook: @drmikehart

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