Dr. Ian Kelleher (University of Edinburgh, Scotland) joins AJP Audio to discuss an emulated target trial looking at the prophylactic qualities of doxycycline, an antibiotic, in an adolescent population at risk to develop schizophrenia spectrum disorder.  Afterwards, AJP Editor-in-Chief Dr. Ned Kalin joins the podcast to put the rest of the issue into context.

  • 00:53   Doxycycline and the risk of developing schizophrenia
  • 04:03   Emulated target trials versus randomized control trials
  • 06:43   Methods of action
  • 09:24   Dosage and exposure levels for doxycycline
  • 10:15   Immediate clinical applications
  • 10:56   Limitations of the study
  • 11:33   Future research
  • 12:43   Kalin interview
  • 13:00   Lång et al.
  • 19:43   Zhao et al.
  • 25:20   Metrik et al.

Transcript

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