October 2026: The RECOVER Trial of Vagus Nerve Stimulation in Markedly Treatment-Resistant Depression: Critical Findings, Lessons Learned, and Future Directions - American Journal of Psychiatry Audio | Lyssna här

Dr. Charles Conway (Washington University School of Medicine, St. Louis) joins the podcast to discuss the RECOVER trial, a RCT that looked at vagus nerve stimulation and its effects on profoundly treatment resistant depression. Following that, AJP Editor-in-Chief Dr. Ned Kalin is joined by the October issue guest editor, Dr. William McDonald (Emory University, Atlanta) to discuss the rest of the October issue, which focuses on neuromodulation and precision therapeutics.

00:42 Conway interview
02:34 Quality of life
05:13 Ethical considerations of a sham arm in this population
07:00 Timing and VNS treatment
08:03 Clinical implications
09:02 Limitations
10:12 Further research
11:30 McDonald and Kalin interview
13:50 Song et al.
14:08 Li et al.
15:44 Donnery et al.
16:38 Valiengo et al.
17:28 Rush
20:03 Mahmoudi
22:37 Conway et al.

Transcript

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