In 1508, Europe’s great powers conspired to dismantle Venice. Pope Julius II, fearing the Republic’s unchecked power on Italian soil, formed the League of Cambrai with France, Spain, and the Holy Roman Empire. This episode explores the dramatic shift in alliances that left Venice isolated and surrounded. We examine the Battle of Agnadello, where Venetian mercenaries suffered a crushing defeat, and the desperate diplomatic maneuvers that saved the Serenissima from extinction. Lucas and Luna discuss how this conflict redefined the balance of power in Renaissance Italy, moving away from Medici intrigue toward statecraft driven by national interest rather than papal whimsy.
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