In this episode of the Peptide Playbook Series, Dr. Din sits down with Dr. Frankel to discuss the science behind testosterone, hormone replacement therapy, peptides, and metabolic health. As we age, many people experience fatigue, weight gain, brain fog, and metabolic changes. According to Dr. Frankel, three major factors often drive these changes: hormone deficiency, insulin resistance, and energy deficiency in the body. In this conversation, we break down how testosterone interacts with estrogen, why self-treating with supplements like DHEA can be misleading, and how therapies such as GLP-1 peptides, NAD, and growth hormone peptides may help restore metabolic balance. We also discuss the differences between menopause, andropause, and the often overlooked "somatopause" — the age-related decline in growth hormone. Topics include:
• Testosterone therapy for men and women
• Hormone replacement and metabolic health
 • Cholesterol and hormone production
• GLP-1 peptides and insulin sensitivity
• Peptides used in longevity medicine
 • The connection between hormones and aging Part of the Peptide Playbook Series, exploring the science behind peptides, metabolism, and modern longevity medicine.
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 00:00 Intro & Welcome Back
01:10 Why Hormone Health Is Misunderstood
 03:30 The Gap in Medical Training (Hormones & Nutrition)
 05:45 Testosterone Basics Explained
08:20 Aging in Men: Testosterone Decline & Estrogen Rise
 11:00 The Truth About DHEA Supplements
14:10 Why Self-Treating Hormones Can Backfire
17:30 Symptoms of Low Testosterone in Men
 20:15 Cholesterol's Role in Hormone Production
23:40 Statins & Their Impact on Hormones
 27:10 Low Testosterone & Metabolic Disease Risks
31:00 Insulin Resistance, Inflammation & Chronic Disease
 34:20 How to Properly Start Hormone Optimization
 38:10 Foundation Protocol: Hormones, NAD, GLP-1
42:00 Testosterone Therapy: Dosing & Approach
45:20 Testosterone in Women: Benefits & Myths
 48:30 Estrogen Dominance & Cancer Risk
51:10 Who Should NOT Take Testosterone?
 53:40 Testosterone & Prostate Cancer Myth Debunked
57:10 Real Study Insights (2019 Shift in Perspective)
 59:10 Final Takeaways on Hormones & Longevity
 01:00:20 Outro & Next Episode Preview (Somatopause)

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