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Denis Noble is the physiologist who built the first computer model of the heart in 1960 — and has spent the sixty years since using it to dismantle the gene-centric view of life that dominates modern biology. He took Richard Dawkins's Selfish Gene and rewrote its most famous passage word for word in reverse — and every single experiment still fits.Expect to learn why the central dogma of molecular biology is provably wrong, how your immune system rewrites its own DNA to fight off new viruses, why the peppered moth story in every biology textbook turns out to be false, what happened when Denis told Richard Dawkins "Lamarck is back" to his face, why a cell corrects roughly 800,000 DNA replication errors before it's allowed to divide, how epigenetic inheritance can persist indefinitely if the environment stays changed, whether plants might have a form of experience, and where exactly agency ends and pure chemistry begins.
Timestamps
0:00:00 Trailer
0:02:27 Meet The Man Who Modeled The Heart By Hand
0:04:43 Why The Central Dogma Of Biology Is Wrong
0:06:39 The 1866 Split Between Darwin And Wallace
0:09:02 The Infinite Monkey Theorem, Tested For Real
0:17:30 The Peppered Moth Myth Textbooks Still Teach
0:20:19 The Nobel Laureate Textbooks Forgot To Cite
0:22:53 Telling Richard Dawkins "Lamarck Is Back"
0:27:43 Was Lamarck's Giraffe Neck Story Actually Right?
0:29:40 How Your Body Talks To Your DNA
0:38:17 A New Species Evolved In Two Generations
0:44:18 So What's Actually Controversial Here?
0:48:09 Cellular Agency: When Cells Act Like Organisms
0:53:04 Steelmanning The Case Against Cellular Agency
0:55:05 The 17th-Century Prediction That Proved Purpose Works
1:04:20 Your Cells Correct 800,000 DNA Errors Per Division
1:13:14 Life Lives On The Edge Of Order And Chaos
1:15:27 Do Plants Have Experience?
1:27:31 How Does Consciousness Fit Into Systems Biology?......
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GS Episodes Mentioned
Michael Levin — Meet the Scientist Creating New Forms of Synthetic Life! Dr Michael Levin: https://www.youtube.com/watch?v=LTBZRVKUwyM
Philip Ball — Philip Ball: "Biology Is Infinitely Weirder Than We Thought": https://www.youtube.com/watch?v=9SseGx0R0fY
Guest Links
Oxford Faculty Page: https://www.dpag.ox.ac.uk/team/denis-noblePersonal Website: https://www.denisnoble.com
Google Scholar: https://scholar.google.com/citations?user=J6kLmsIAAAAJ&hl=en
Understanding Living Systems (Book): https://www.amazon.com/Understanding-Living-Systems-Life/dp/1009277367
The Third Way of Evolution: https://www.thethirdwayofevolution.com/people/view/denis-noble
