What do you call a small B-cell lymphoma that isn't CD5 positive, isn't CD10 positive and generally refuses to wear any of the usual hats? Probably marginal zone lymphoma. Possibly. Maybe.
Join the Bloody Minded crew as we head to the edge of the follicle where the bloodstream's customs officers live, and look at what happens when they go rogue. Discover how to cure a cancer with a PPI, and why we're so very bored of the NF-κB pathway.
TIMESTAMPS
0:57 - Whisky sponsorship pls and thx 2:11 - What the marginal zone is/isn't 6:28 - Marginal zone B cells 8:35 - Classifying marginal zone lymphoma 11:05 - Epidemiology 12:09 - Pathophysiology in gastric MALT 16:42 - Stimuli for other marginal lymphomas 19:55 - Pathological features of marginal 21:20 - Splenic MZL 25:43 - Flow cytometric features 30:13 - Workup of MZL 32:20 - Management strategies 37:53 - Prognosis 38:56 - High grade transformation 40:07 - Take home messages
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