Anaphylaxis

Anaphylaxis explained including anaphylaxis pathophysiology (immunologic vs non immunologic), clinical features, diagnosis, and treatment. Includes recognition of airway compromise, use of intramuscular adrenaline (epinephrine), biphasic anaphylaxis, refractory anaphylaxis, and the immunology underlying type 1 hypersensitivity reactions. 

PDFs available at: https://rhesusmedicine.com/pages/topics

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Timestamps:
0:00 What is Anaphylaxis?
0:32 Anaphylaxis Pathophysiology
4:08 Anaphylaxis Causes
5:28 Anaphylaxis Symptoms
7:44 Anaphylaxis Diagnosis
8:32 Anaphylaxis Treatment

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References

1. BMJ Best Practice (2025) Anaphylaxis – Symptoms, diagnosis and treatment. Available at: https://bestpractice.bmj.com/topics/en-gb/501
2. British Society for Immunology (2021) Anaphylaxis. Available at: https://www.immunology.org/public-information/bitesized-immunology/immune-dysfunction/anaphylaxis
3. RCEMLearning (2023) Anaphylaxis. Available at: https://www.rcemlearning.co.uk/reference/anaphylaxis/
4. Simons, F.E.R., Ardusso, L.R.F., Bilo, M.B., El-Gamal, Y.M., Ledford, D.K., Ring, J., Sanchez-Borges, M., Senna, G.E., Sheikh, A. and Thong, B.Y. (2018) World Allergy Organization anaphylaxis guidance 2018. Journal of Allergy and Clinical Immunology, 141(2), pp. 419–420.e1. Available at: https://www.jacionline.org/article/S0091-6749(18)30571-2/fulltext
5. Turner, P.J., Worm, M., Ansotegui, I.J. and El-Gamal, Y.M. (2024) IgE and non-IgE-mediated pathways in anaphylaxis. Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC12350582/
6. Cardona, V., Ansotegui, I.J., Ebisawa, M., El-Gamal, Y., Fernandez Rivas, M., Fineman, S., Geller, M., Gonzalez-Estrada, A., Greenberger, P.A., Sanchez Borges, M., Senna, G., Sheikh, A. and Tanno, L.K. (2020) ‘World allergy organization anaphylaxis guidance 2020’, World Allergy Organization Journal, 13(10), p. 100472. doi:10.1016/j.waojou.2020.100472.

Please remember this podcast and all content from Rhesus Medicine is meant for educational purposes only and should not be used as a guide to diagnose or to treat. Please consult a healthcare professional for medical advice.