“What do you think about peptides?” is one of the most common questions in the sleep clinic right now, and it’s about as answerable as “What do you think about sandwiches?” Insulin, Zepbound and a gray-market vial of BPC-157 are all peptides, but the word tells you nothing about what a molecule does or how well it’s been tested. In this episode we put the most popular “sleep peptides” to the test, including the one named after deep sleep that an FDA advisory panel rejected this summer while backing nearly everything else. In this episode we will:
Define what a peptide is, including the FDA’s somewhat arbitrary 40-amino-acid line, and why most have to be injected
Sort out supplements, FDA-approved drugs, compounded drugs and “research use only” vials, and walk through 2026’s regulatory saga
List the risks posed by unregulated peptides
Rank the sleep evidence, from tirzepatide’s sleep apnea trials to the stories behind DSIP, epitalon and the growth-hormone peptides
Leave you with five questions to ask anyone recommending “peptides"
Original intro music Vigilanteology by Abhinav Singh (copyright 2026)
Original outro music Vigilanteology (reprise) by Abhinav Singh (copyright 2026)
Produced by: Maeve Winter
Music by: Dr. Abhinav Singh (@sleep_vigilante), all rights reserved
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