SSRI，全称 selective serotonin reuptake inhibitor，中文叫做选择性血清素再摄取抑制剂，是目前全球使用最广泛的抗抑郁药物。百忧解、左洛复、来士普，这些名字你可能不陌生。仅在美国，2023年就有约11.4%的成年人在服用抗抑郁药物处方。在全球抗抑郁药市场中，SSRI 占据了超过55%的份额，市场规模在2024年达到187亿美元，而且还在持续增长。
这类药物之所以能走到今天的位置，背后有一个支撑它的理论——「血清素假说」，也就是抑郁症是因为大脑里的血清素不足。这个假说塑造了几十年来医生开药的逻辑，也塑造了无数患者对自己疾病的理解方式。但问题在于，这个理论从来没有在人体上被直接证明过。
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