New Amsterdam Hospital is on lockdown as inmates from Rykers Island are roaming the halls of the hospitals with guns and knives. Dr. Rynolds is critically stabbed as he is performing a life saving surgery. Dr. Max and Dr. Sharp are taken hostage by inmate Jackie and she threatens to kill them if they don't take her to the O.R. where Reynolds is performing his surgery. Dr. Frome and his husband Martin confront their marital issues as they are on the verge of breaking up for good.

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