šŸ§¬ Can atherosclerosis become lethal even without high cholesterol?

A fascinating Cell study identifies GIMAP6 as an immuneā€“vascular safeguard. Loss of GIMAP6 disrupts endothelial integrity and activates a mitoROS ā†’ PPARĪ³ ā†’ CD36 pathway, driving macrophage lipid uptake, foam cells, inflammation, atherosclerosis, MI and heart failureā€”even without hyperlipidemia. ā¤ļø

Human hypomorphic GIMAP6 variants also tracked with premature cardiovascular disease.

šŸ’” Take-home: LDL matters enormouslyā€”but susceptibility within the vessel wall matters too.

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