More than six years after the COVID-19 outbreak began, its origin remains unresolved, leaving an important question about which risks pandemic prevention efforts need to address
Bill Gurley argues that major catastrophes such as Challenger, Fukushima and the Boeing 737 MAX crashes received extensive root-cause investigations that offer a model for examining COVID-19's origins
The CAPA framework follows five steps — detect, investigate, confirm the root cause, correct and prevent — because effective safeguards depend on knowing what produced the original failure
The DEFUSE proposal described plans to insert a furin cleavage site into a bat coronavirus, a feature also found in SARS-CoV-2, making it an important investigative lead but not proof of a lab origin
You can apply root-cause thinking to health and everyday decisions by separating evidence from interpretation, checking original sources, considering conflicts of interest and directing solutions at the underlying cause
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