In a laboratory study, erythritol disrupted several functions in cultured human brain blood vessel cells, raising concerns that its effects extend beyond blood sugar and calorie content
Erythritol increased oxidative stress while reducing nitric oxide production by about 20%, interfering with a key process that helps your blood vessels relax and regulate blood flow
The sweetener increased production of endothelin-1, which promotes blood vessel constriction, by about 30%, further shifting the balance away from healthy blood vessel function
Erythritol-treated cells failed to activate their normal clot-clearing response when researchers exposed them to a clotting signal, suggesting another way the sweetener could interfere with healthy brain blood vessel function
Avoiding erythritol starts with checking ingredient lists — it appears in many products not obviously marketed as sugar-free — and choosing natural sweeteners like ripe fruit, raw honey or maple syrup in moderation rather than replacing it with another artificial substitute
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