Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis

In this episode, Sam Ashoo, MD and Dr. T.R. Eckler, MD discuss the July 2026 Emergency Medicine Practice article, Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: Diagnosis and Management in the Emergency Department.

• 0:17 – Intro & sponsor promo
• 1:09 – Episode introduction
• 4:03 – Definitions: SJS vs. TEN vs. "overlap" by body surface area
• 6:12 – Pathophysiology
• 9:52 – Incidence and rarity of the disease
• 10:53 – Differential diagnosis & clinical presentation clues
• 12:08 – Prehospital care & fluid resuscitation considerations
• 13:47 – ED history-taking: medications, infections, rash progression
• 14:47 – Physical exam findings
• 16:46 – Diagnostic studies
• 18:12 – Scoring systems: SCORTEN and ABCD-10
• 20:50 – Treatment goals
• 23:57 – Wound care principles
• 24:43 – Mechanical ventilation risk factors
• 26:02 – Other possible therapies
• 27:50 – Specialty consults & special populations
• 29:06 – Ophthalmologic treatment
• 31:17 – HIV patients and elevated risk
• 31:55 – Emerging therapies & AI-based diagnostic tools
• 32:57 – Five key clinical takeaways
• 34:37 – Closing remarks & sponsor sign-off

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