In this episode, Sam Ashoo, MD and Dr. T.R. Eckler, MD discuss the September 2026 Emergency Medicine Practice article, Emergency Department Diagnosis and Management of Acetaminophen or Salicylate Toxicity
1:13 — Welcome and topic introduction
3:50 — Key rules: check levels, call Poison Control
5:13 — Acetaminophen pathophysiology
8:16 — Salicylate pathophysiology
10:51 — Coingestions
11:11 — Differential diagnosis
12:19 — History & pre-hospital care
15:28 — Product confusion
17:08 — Toxic dose thresholds
18:26 — Physical exam & vital signs
20:16 — Acetaminophen toxicity stages (1-4)
22:35 — Salicylate exam findings
23:43 — Lab workup & testing
24:45 — Acetaminophen nomogram & levels
30:39 — Activated charcoal — when to give it
34:11 — NAC therapy — dosing & timing
37:22 — Hemodialysis for acetaminophen
38:40 — King's College Criteria
41:00 — Salicylate treatment
44:42 — Potassium management during alkalinization
47:28 — Hemodialysis for salicylate
48:05 — Intubation
50:00 — Pregnancy considerations
51:20 — Pediatric considerations
52:06 — Emerging: fomepizole as adjunct therapy
52:45 — Summary & wrap-up
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