ESC recaps on the SINGLE-AF trial, CMR Guide trial, two ATTR studies, PVI-SHAM-AF, STAREE, and an observational study of ICD benefit over the past decades are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I SINGLE-AF Trial
To Anticoagulate or Not in Intermediate-Risk AF: The SINGLE-AF Trial https://www.medscape.com/viewarticle/anticoagulate-or-not-intermediate-risk-af-single-af-trial-2026a1000uko
- SINGLE-AF https://www.nejm.org/doi/10.1056/NEJMoa2607978
II Scar as an ICD risk stratifier
Is Scar on CMR an Indication for ICD? CMR Guide Leaves Doubts
https://www.medscape.com/viewarticle/scar-cmr-indication-icd-cmr-guide-leaves-doubts-2026a1000ukq
- CMTR GUIDE Trial https://jamanetwork.com/journals/jama/fullarticle/2853395
- MADIT II Trial https://www.nejm.org/doi/full/10.1056/NEJMoa013474
III Single vs Dual Therapy in ATTR-CM
- HELIOS-B Trial Sub-analysis https://www.sciencedirect.com/science/article/pii/S0735109726072086
- HELIOS-B Sub-analysis Editorial https://www.sciencedirect.com/science/article/pii/S0735109726073766#bib8
- HELIOS-B main trial https://www.nejm.org/doi/10.1056/NEJMoa2409134
- CARDIO-TTRansform Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2608510
IV A Stunning Result of another Sham-controlled AF ablation trial
Does AF Ablation Work? That's in Question After PVI-SHAM-AF https://www.medscape.com/viewarticle/does-af-ablation-work-s-question-after-sham-pvi-af-2026a1000uli
- PVI-SHAM-AF Trial 10.1016/S0140-6736(26)01558-8 External Link
- SHAM-PVI Trial https://jamanetwork.com/journals/jama/fullarticle/2823283
- PFA-Sham Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.079484
V Should Older Adults Take Statins: The STAREE trial.
STAREE Strengthens Case for Over-the-Counter Statins https://www.medscape.com/viewarticle/staree-strengthens-case-over-counter-statins-2026a1000vrw
- STAREE Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2607314
VII Declining ICD Benefit After MI
- Mortality Reduction with ICD for Prevention of SCD Post-MI https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehag706/8768943
- CONTEMP-ICD Trial https://clinicaltrials.gov/study/NCT06543446
- PROFID-EHRA Trial https://profid-project.eu/profid-ehra-trial/
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
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