Genitourinary Cancers — 5-Minute Journal Club Issue 1 with Professor Thomas Powles: Current and Future Role of Tumor-Informed Circulating Tumor DNA Assays

Interview conducted on March 11, 2026, by Dr Neil Love, including the following topics:

• Circulating tumor DNA (ctDNA)-guided adjuvant therapy with atezolizumab for muscle-invasive bladder cancer (MIBC) (0:00)
• Use of ctDNA in guiding systemic treatment selection for patients with urothelial bladder cancer (10:03)
• ctDNA analyses with perioperative durvalumab for MIBC in the Phase III NIAGARA study (16:51)
• New research advances in the monitoring and management of urothelial bladder cancer (22:21)

CME information and select publications