An English-language clinical discussion designed exclusively for physicians.

This episode uses a fictional pulmonary embolism case to explore risk stratification, right ventricular dysfunction, reperfusion decisions, anticoagulation, multidisciplinary care, and follow-up.


We discuss the 2026 AHA/ACC multisociety guideline, the 2019 ESC framework, and benefit–harm findings from PEITHO and HI-PEITHO. HI-PEITHO is presented as subsequent trial evidence published after the February 2026 guideline.


AI-generated voices are used for the discussion. The patient case is fictional, and the diagrams are illustrative. This episode is educational and is not accredited continuing medical education.


References:

2026 AHA/ACC guideline: doi:10.1161/CIR.0000000000001415

2019 ESC guideline: doi:10.1093/eurheartj/ehz405

PEITHO: doi:10.1056/NEJMoa1302097

HI-PEITHO: doi:10.1056/NEJMoa2516567

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