Visceral fat, subcutaneous fat, Prenuvo MRI scans, and the truth about belly fat
Your gut and your face are telling on you. This episode reveals why the fat under your skin might be protecting you while the fat around your organs is quietly wrecking your metabolism, heart, and longevity, and exactly what to do about the difference.
Get $300 off your next Prenuvo MRI scan: https://prenuvo.com/?discount=Dave
Host Dave Asprey sits down with Dr. Sean O'Mara, a former undercover narcotics agent, criminal prosecutor, emergency medicine physician, and retired U.S. Army Colonel who assisted the White House and Senior Executive Service, treating Vice President Dick Cheney, former President Bill Clinton, and Secretary of State Colin Powell. Today he's recognized as the world's most experienced physician in eliminating visceral fat and epicardial adipose tissue (EAT), the inflammatory fat now linked to nearly every major chronic disease and accelerated aging. He founded Influence Medicine, a specialty built around helping senators, heads of state, and top executives optimize their biology so they can perform and lead at the highest level.
Dave and Dr. O'Mara break down the real difference between visceral fat and subcutaneous fat, why a visible six-pack might signal hidden disease, and how MRI scans reveal what your mirror never will. They dig into the biohacking strategies that actually shift your body composition: fasting protocols that build beneficial fat instead of burning it away, microbiome optimization for fat metabolism, and the supplements and functional medicine tools Dr. O'Mara uses with his highest-performing clients. They also cover the gut-hormone connection driving modern metabolic dysfunction, why political leaders are quietly getting scanned, and what your face reveals about your visceral fat levels before you ever step on a scale.
You'll Learn:
- The real difference between visceral fat, subcutaneous fat, and why one protects you while the other kills you
- Why a six-pack might be hiding disease your MRI would catch
- How a 72-hour fasting protocol can build the good kind of fat through adiponectin signaling
- What your face reveals about your visceral fat and longevity risk
- The gut-hormone connection driving testosterone, metabolism, and inflammation
- Why senators and world leaders are getting scanned for hidden fat
- How microbiome health, fasting, and functional medicine work together for fat loss and longevity
Thank you to our sponsors!
- Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com.
- Suppgrade Labs | Get real restorative sleep with Quiet Mode. Use code DAVE15 at shopsuppgradelabs.com.
- Puori | Use code DAVE at puori.com/DAVE to get 32% off your first Puori CP1 Pure Collagen. Order when you start a subscription. You save more than $26
- LMNT | Right now you can get a free 8-count Sample Pack of LMNT's most popular drink mix flavors with any purchase at drinkLMNT.com/dave
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.
New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.
Keywords: visceral fat vs subcutaneous fat, how to reduce visceral fat, best fat for longevity, MRI body scan benefits, Prenuvo full body scan, what is epicardial fat, skinny fat TOFI explained, why is my six pack unhealthy, 72 hour fasting benefits, fasting and testosterone, how to build subcutaneous fat, biohacking visceral fat, Sean O'Mara doctor, influence medicine, fecal microbiota transplant benefits, gut microbiome and fat loss, Dave Asprey, biohacking, longevity
Resources:
• Learn More About Dr. O’Mara’s Work At: https://drseanomara.com/
• Get $300 Off Your Next Prenuvo MRI Scan: https://prenuvo.com/?discount=Dave
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15?
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com
Timestamps:
00:00 – Trailer
00:58 – Intro
02:38 – Fat Type Basics
04:19 – Reviewing Dave's Scan
08:04 – Good Fat vs. Bad Fat
16:49 – Fertility & Pregnancy
19:47 – Personality & Health
21:51 – Wealth & Health Neglect
30:32 – Insurance Incentives
39:29 – Microbiome & Disease
40:41 – FDA & Fecal Transplants
42:57 – Viome & Biomarker Data
45:40 – Skinny Fat & Appearance
49:44 – Building Subcutaneous Fat
52:57 – Fasting Protocol
58:37 – Closing
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.