Vitamin D levels advised

Read the link to the original paper, https://www.mdpi.com/2072-6643/13/10/3596Uploaded 17-11-21Deficiency of vit D limits the performance of systems resulting in, increased spread of diseases of civilizationReduced protection against infectionsReduced effectiveness of vaccination Covid fatality rates correlate with,Elderly, dark, black people, comorbidities, winterBlood level of 20 ng/mL, (50 nmol/L) sufficient to stop osteomalaciaPreferable, 40–60 ng/mL (100 to 150 nmol/L)Vitamin D3 receptorsBoneIntestinePancreasProstateImmune system cellsVitamin D is a powerful epigenetic regulatorInfluencing more than 2,500 genesCancerDiabetes mellitusAcute respiratory tract infectionsViral lung infections that cause ARDSChronic inflammatory diseasesAutoimmune diseasesMultiple sclerosisImmunomodulatory propertiesRegulating innate and adaptive immune systemsD3 receptors Monocytes/macrophagesT cellsB cellsNatural killer (NK) cellsDendritic cells (DCs)SupplementsWithout calcium supplementation, even very high vitamin D3 supplementation does not cause vascular calcificationVitamin D3 supplementation in the range of 4000 to 10,000 units (100 to 250 µg) needed to generate an optimal 40–60 ng/mL (100 to 150 nmol/L)has been shown to be completely safe when combined with approximately 200 µg vitamin K2https://www.nhs.uk/conditions/vitamins-and-minerals/vitamin-k/However, this knowledge is still not widespread in the medical community, and obsolete warnings about the risks of vitamin D3 overdoses unfortunately are still commonly circulating.ARDS and cytokine release syndromeVitamin D3 is able to inhibit the underlying metabolic pathwaysVitamin D3 has a protective role against ARDS caused by SARS-CoV-2. A rapidly increasing number of publications are investigating the vitamin D3 status of SARS-CoV-2 patients,and have confirmed low vitamin D levels in cases of severe courses of infection and positive results of vitamin D3 treatments Conclusionswe recommend raising serum 25(OH)D levels to above 50 ng/mL (100 to 150 nmol/L)to prevent or mitigate new outbreaks due to escape mutations or decreasing antibody activity.At a time when vaccination was not yet available,patients with sufficiently high D3 serum levels preceding the infection were highly unlikely to suffer a fatal outcome. This correlation should have been good news when vaccination was not available but instead was widely ignored. the lower threshold for healthy vitamin D levels should lie at approximately 125 nmol/L or 50 ng/mL 25(OH)D3,which would save most lives, reducing the impact even for patients with various comorbidities.This is—to our knowledge—the first study that aimed to determine an optimum D3 level to minimize COVID-19 mortalityImplications for herd immunityIt seems clear that a good immune defense, does not prove protection against physical infection but rather against its consequencesThis “protection” was most effective at ~55 ng/mLTraditionally living populations in East Africa have a mean serum 25-hydroxyvitamin D concentration of 115 nmol/lhttps://www.cambridge.org/core/journals/british-journal-of-nutrition/article/traditionally-living-populations-in-east-africa-have-a-mean-serum-25hydroxyvitamin-d-concentration-of-115-nmoll/6188564A01361C5CF5F196229430E475natural vitamin D3 levels seen among traditional hunter/gatherer lifestyles,in a highly infectious environment, were 110–125 nmol/L (45–50 ng/mL)WHO advice may not be correct30 ng/mL D3 value considered by the WHO as the threshold for sufficiencyFuture mutations of the SARS-CoV-2 virus, vaccine immune escapethe entire population should raise their serum vitamin D level to a safe level as soon as possible. As long as enough vitamin K2 is provided, the suggested D3 levels are entirely safe to achi Learn more about your ad choices. Visit megaphone.fm/adchoices