Lancet February 2026 Cyclic exclusive enteral nutrition versus partial enteral nutrition to maintain long-term drug-free remission in paediatric Crohn's disease (CD-HOPE): an open-label, endpoint-blinded, randomised controlled trial

This research study investigated whether specialized liquid diets could successfully maintain long-term clinical remission in children with Crohn's disease without the need for traditional pharmaceutical drugs. Researchers compared two distinct methods: a cyclic approach involving two-week bursts of an exclusive liquid diet every two months, and a partial approachwhere patients consumed a small portion of their daily calories as liquid formula alongside regular food. The results demonstrated that the cyclic method was significantly more effective at preventing disease relapses over the course of a year. By prioritizing nutritional intervention over medication, this trial highlights a promising dietary strategy for managing pediatric illness while avoiding the potential side effects associated with long-term drug use.