Aspirin is having a moment. From inflammation and pain to cancer prevention, brain health, metabolism, and even thyroid function, you’ve probably heard some pretty impressive claims about what this little drug can do.
But how much of it is actually supported by science?
In this episode of Metabolic Mindset, we take a deep dive into Ray Peat’s article “Aspirin, Brain, and Cancer” and unpack the physiology behind his ideas. We’ll explore aspirin’s effects on prostaglandins, inflammation, polyunsaturated fatty acids, mitochondrial function, glucose metabolism, estrogen, cancer biology, the brain, and more.
More importantly, we’ll separate interesting mechanisms from actual clinical evidence.
What did Peat get right? Where was his reasoning ahead of the research? And where does a plausible physiological mechanism become an unsupported leap?
This is not an episode telling you to take aspirin. It’s an exploration of how to critically evaluate physiological theories, understand what the research actually shows, and recognize the difference between a fascinating hypothesis and a clinical recommendation.
Because we don’t do dogma—we do physiology.
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