The Shkreli Pill
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Episode 1050: How I Lost Big Shorting Kodiak. Open AI Going Public. Why Most Financial Models Fail

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In this episode, Martin reflects on a costly short position in Kodiak Sciences and examines what went wrong with the trade, including the risks of conviction, timing, and unexpected catalysts. He also discusses the possibility of OpenAI eventually going public and what such a move could mean for investors, before explaining why he believes many financial models fail to capture reality and how assumptions, probabilities, and changing business conditions can undermine even detailed forecasts.

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