If you’ve noticed that caffeine, alcohol, supplements, stress, or even fragrances affect you differently than they used to, this episode will help explain why.
In this episode, Lauri explores how detox and methylation pathways work behind the scenes — and why these systems can feel more noticeable after 45 as hormones and genetics interact differently than before.
You’ll learn how:
Detox and methylation function as daily biological systems, not cleanses
Estrogen changes increase the importance of detox pathways in midlife
Stress chemistry places added demand on clearance pathways
Key genes like COMT, GSTM1, MTHFD1, and NAT2 shape tolerance and recovery
Simple, consistent habits support detox without extremes
This episode is especially helpful if you’ve experienced increased sensitivity to caffeine or alcohol, stress that lingers longer, stronger reactions to supplements, or changes in sleep quality after 45.
Resources Mentioned:
View the Midlife Genomics Series — a six-part article series explaining what genomics is and how to understand your own results.
A short guide explaining how estrogen is processed after it’s used, why hormone levels don’t always tell the full story, and how genetics may help explain another layer of estrogen biology.
This podcast is for educational purposes only and is not intended to diagnose, treat, or provide medical advice. The information shared reflects general biological and genetic principles. Always consult a qualified healthcare professional regarding your own health decisions.
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