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Drs. Jason Mouabbi, Ruta Rao, & Mark Pegram - Unpacking DESTINY-Breast09 in HER2+ mBC

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A new era in HER2-positive metastatic breast cancer is here.Dr. Jason Mouabbi, Dr. Ruta Rao, and Dr. Mark Pegram break down the groundbreaking DESTINY-Breast09 trial and discuss how trastuzumab deruxtecan (T-DXd) plus pertuzumab is redefining first-line treatment.


The conversation explores:

  • Why DB09 may replace the CLEOPATRA standard
  • The significance of 40+ month median PFS
  • Complete response rates and treatment durability
  • Managing ILD, fatigue, nausea, and alopecia
  • Maintenance therapy strategies
  • PATINA and HER2CLIMB-05 insights
  • Sequencing after T-DXd progression
  • Why “saving your best drug for later” may no longer apply


This is a must-watch discussion on the evolving frontline landscape in HER2+ metastatic breast cancer.

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