The paper introduce the KP-Tracer mouse model, an innovative genetic system designed to continuously track the evolution of lung adenocarcinoma at single-cell resolution. By combining Cas9-based lineage tracing with single-cell RNA sequencing, researchers can map the intricate phylogenetic relationships and fitness landscapes of developing tumors from a single transformed cell. The findings reveal that tumor expansion is driven by rare subclones acquiring specific transcriptional profiles and DNA copy number variations, often progressing through distinct gene modules associated with cellular plasticity and aggressiveness. Furthermore, analyses of these subclonal dynamics demonstrate that increased cell fitness and specific transcriptional signatures strongly correlate with poor prognoses in human lung cancer patients.
References:
Yang D, Jones M G, Naranjo S, et al. Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution[J]. Cell, 2022, 185(11): 1905-1923. e25.
Podden och tillhörande omslagsbild på den här sidan tillhör
淼淼Elva. Innehållet i podden är skapat av 淼淼Elva och inte av,
eller tillsammans med, Poddtoppen.
