Trevor Manz went from measuring plant apertures by hand in a wet lab to building the notebook that lets coding agents take the wheel. The creator of anywidget and founding engineer at marimo (marimo.io/pair) popped into The Test Set to spill on reactive notebooks, why marimo pair threw out every MCP tool but one, and what agents really want out of a data environment. This conversation also features a jacket bouncer, a hidden Python API, and Michael's slow-motion war with the word "marimo."

What's inside:

  • Cell order doesn't matter in a reactive Python notebook
  • Wet-lab pipettes and Harvard's visualization group, via Raspberry Pi
  • The problem with building beautiful tools nobody actually uses
  • The reason marimo pair deleted every agent tool but one
  • Code mode: the hidden API humans aren't supposed to touch
  • What happens when you ship the API your LLM hallucinated

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