Thank you to our partner Astellas for their support in producing this podcast episode.
Claudin-18.2 (CLDN18.2) represents an important emerging biomarker in gastrointestinal cancer.
In this episode of The Pathology Report, host Dr Donna Lenghaus is joined by Professor Beena Kumar and A/Professor Katrin Sjoquist to discuss the evolving role of biomarkers in the management of gastric carcinoma, and how CLDN18.2 testing can help identify patients who may benefit from targeted therapies.
Key topics discussed include:
- How improved understanding of tumour biology and identification of biomarkers is changing the management of gastrointestinal cancers.
- The clinical utility of using CLDN18.2 testing to facilitate targeted therapies for eligible patients, including Zolbetuximab.
- Pathology considerations, including appropriate biopsy, controls, specimen age, tumour location, scoring and reporting standards.
- The role of the multidisciplinary team.
- Resources and other emerging biomarkers.
In exploring the use of CLDN18.2 as a predicative biomarker, this episode highlights that accurate immunohistochemistry testing, adequate tissue, standardised reporting and strong communication between pathology and clinical teams is essential to ensuring eligible patients can access targeted treatments.
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