Dr. G explains how hypoxia‑inducible factor 1 alpha (HIF‑1α) acts as the cell's oxygen sensor and coordinator of wound repair, why diabetes disrupts its signaling, and how that impairment stalls healing in diabetic foot ulcers.
The episode summarizes how researchers measure HIF‑1α, and reviews emerging treatments—HIF stabilizers, gene/RNA therapies, stem cells, engineered scaffolds, and oxygen‑releasing biomaterials—that aim to restore molecular healing pathways and improve limb salvage.
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