Join host Dr. David Ahn and guest Dr. Michael Haller (Professor and Chief of Pediatric Endocrinology at the University of Florida and Chair of TrialNet) as they take a comprehensive review of the evidence base and remaining gaps for inhaled insulin use in pediatric and adolescent populations
In this final episode, we dive into:
Key Challenges in Pediatrics: Unmet needs in pediatric insulin therapy, including injection fatigue and tech-retention issues for active youth.
The INHALE-1 Study: A deep dive into the randomized controlled trial data of 230 youth, highlighting efficacy, per-protocol non-inferiority, less weight gain, and superior treatment satisfaction among kids and parents.
Safety Profile: Analyzing forced expiratory volume (FEV1) data showing an excellent safety signal with no differences in pulmonary function or severe hypoglycemic events.
Practical Toolkit Use Cases: How the unique pharmacokinetic profile of inhaled insulin provides unmatched benefits for covering adrenaline-rush highs and avoiding hypoglycemia tail effects during sports and exercise.
Dosing Guidelines: Overcoming the practical "paradigm shift" of converting injected units to inhaled units and managing dosing effectively.
Future Horizons: Anticipating the "INHALE FIRST" study investigating early onboarding for newly diagnosed patients and introducing a new two-unit inhaled insulin cartridge.
About ATTD Diabetes Talks:
A podcast series dedicated to providing healthcare professionals with the latest knowledge and best practices in diabetes management, supported by MannKind Corporation.
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Chapters:
00:00 Intro and Unique Challenges in Pediatric Diabetes Management
02:38 The INHALE-1 Study: Efficacy, Satisfaction, and Weight Findings
06:27 Safety Signals, Pulmonary Function, and Adherence Challenges
10:18 Practical Toolkit Use Cases: Managing Sports and Exercise
12:48 Dosing Conversions and Practical Patient Selection Guidelines
15:02 Off-Label Integration with Automated Insulin Delivery (AID) Systems
20:14 Caregiver & School Nurse Roles and Managing Safety Concerns
22:00 Research Gaps, The INHALE FIRST Trial, and Wrap Up
