Electrophysiology, Schwann Cell Biology, and the Neurophysiological Mechanisms of Leprosy Neuropathy

Hosts:

• Camila Pupe – Professor of Neurology, Universidade Federal Fluminense, Brazil

• Wilson Marques Jr. – Professor of Neurology, University of São Paulo School of Medicine – Ribeirão Preto

Guests:

• Einar Wilder-Smith – Professor of Neurology, University of Bern, Switzerland

• Pedro Jose Tomaselli – Neurology Department, University of São Paulo, Ribeirão Preto

This episode explores the neurophysiological mechanisms underlying leprosy neuropathy, emphasizing how interactions between Mycobacterium leprae, Schwann cell biology, and host immune responses manifest in electrophysiology. The discussion highlights the distinctive neurophysiological "fingerprint" of leprosy neuropathy and the evolution of diagnostic approaches—from standard nerve conduction studies to multisite protocols and advanced ultrasound techniques.

This episode brings together leading experts in the field, offering rich insights that integrate basic science, clinical neurology, and emerging diagnostic tools.