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You can feel good about your GLP-1 weight loss and still wonder why your face looks different. Ana Reisdorf, Registered Dietitian and GLP-1 user, talks with wound-healing scientist Brian Pilcher, PhD, about what people call "Ozempic face," how volume loss differs from loose skin, and the treatment options available today. Could future treatments help the body rebuild some of its own tissue?
Brian explains the science behind tissue regeneration and what his company, Conexeu Sciences, is studying. Its technology remains preclinical, with safety and effectiveness still to be established in human trials.
**IN THIS EPISODE**
- How weight loss can change facial volume and skin support
- The differences between fillers, biostimulators, and skin-tightening treatments
- Why tissue regeneration involves cells, biological signals, and a supporting framework
- What early research can tell us, and what still needs to be tested in people
- Why wound-care development and potential aesthetic applications have different timelines
- Unanswered questions about GLP-1s and skin, plus caution around exosome claims
**ABOUT THE GUEST**
Brian Pilcher, PhD, is a wound-healing biologist and Chief Medical Officer of Conexeu Sciences. He brings more than 25 years of experience in dermatology and aesthetics, including leadership roles at BioForm Medical, Merz North America, and Suneva Medical. He holds a doctorate in cell and molecular biology from the University of Oklahoma College of Medicine. His research career included postdoctoral work at Washington University in St. Louis and a faculty position studying wound repair at UT Southwestern Medical Center. Today, his work focuses on translating tissue-repair science into the development of medical devices and potential regenerative treatments.
**CONNECT WITH BRIAN**
Conexeu Sciences: https://www.conexeu.com/
**SPONSORS**
Tyde Wellness offers clinician-guided GLP-1 care and ongoing support. Get $50 off your first month with code GLP1Hub50.
https://tydewellness.com/GLP1Hub
Calocurb is an appetite-support supplement made with Amarasate hops extract. Use code ANA10 for 10% off.
https://www.calocurb.com/
**CHAPTERS**
00:00 Facial changes after GLP-1 weight loss
05:23 What people mean by "Ozempic face"
08:58 What tissue regeneration actually means
13:51 Sponsor: Tyde Wellness
15:17 Targeting different tissues
16:27 Fillers, biostimulators, and skin tightening
21:27 What researchers still need to prove about safety
22:52 Human studies and the development timeline
26:32 Combining treatments and deciding when to start
28:23 Sponsor: Calocurb
29:22 Unanswered questions about GLP-1s and skin
30:45 Future research and caution around exosomes
33:42 Where to learn more and breast-tissue research
35:05 Stay connected with GLP-1 Hub
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*The content of this show is for informational purposes only and does not constitute medical advice. The goal of this show is to provide various points of view about GLP-1 Medications. The personal and professional opinion of the guests and their content does not necessarily reflect the opinion of Ana Reisdorf or GLP-1 Hub.
