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Muscle is one of the body's biggest metabolic organs, and it matters even more on a GLP-1. Registered dietitian Ana Reisdorf and Dr. Caitlyn Edwards, PhD, RD, Senior Research Scientist at AG1, look at what the research shows about muscle loss on GLP-1s, why the fear around it is often overblown, and how creatine and HMB may help protect muscle alongside protein and strength training. Recorded Live at FNCE 2026.
**IN THIS EPISODE**
- Why muscle matters for both physical and metabolic health
- Lean mass vs. fat mass, and how to measure your own body composition
- How much of the weight lost on a GLP-1 is actually muscle
- How GLP-1s compare with dieting and bariatric surgery for lean mass loss
- Creatine: what it does, the research-backed daily dose, and why consistency matters
- HMB: how it helps build and protect muscle
- What the early research says about combining creatine and HMB
- What's new in AG1 Pro, and where to follow AG1's GLP-1 research
**ABOUT THE GUEST**
Dr. Caitlyn Edwards, PhD, RD, is a Senior Research Scientist at AG1. She earned her doctorate in Nutritional Sciences at the University of Illinois at Urbana-Champaign and completed post-doctoral training at Penn State. She has published more than 50 peer-reviewed articles on nutrition, neuroscience, technology, and eating behavior. She is also a Registered Dietitian, certified in obesity care for children and adults.
**CONNECT WITH DR. CAITLYN EDWARDS**
X: https://x.com/Caitlyn052590
AG1 Science: https://drinkag1.com
Find clinical trials: https://clinicaltrials.gov
**SPONSORS**
Thank you to AG1 for sponsoring this episode. Learn about AG1 Pro and the science behind it at https://drinkag1.com
Hero Bread: bread, bagels, and pizza crusts with more protein and fiber built in. Use code GLP1Hub for 10% off at https://hero.co
Soy Nutrition Institute Global, with support from US Soy: evidence-based resources on GLP-1 medications and plant-forward eating at https://sniglobal.org/emerging-obesity-medications
**CHAPTERS**
00:00 Muscle is a metabolic organ
00:50 Intro: FNCE series with AG1
02:00 Meet Dr. Caitlyn Edwards
03:00 Why supplement brands now study their own products
05:30 Do GLP-1s eat your muscle (or your heart)?
07:00 Lean mass vs. fat mass, and how to measure yours
10:00 How much of the weight you lose is muscle
12:30 GLP-1s vs. diet and bariatric surgery
14:04 Sponsor: Hero Bread
15:00 Calories, protein, and strength training first
16:00 Creatine: what it does and how much to take
21:00 HMB: building and protecting muscle
23:30 Safety, and combining creatine with HMB
24:28 Sponsor: Soy Nutrition Institute Global
25:30 What's new in AG1 Pro
27:30 Where to follow AG1's GLP-1 research
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*Some of the links shared are affiliate links. When you make a purchase, I will receive a small commission at no cost to you. Thank you for supporting the show.
*The content of this show is for informational purposes only and does not constitute medical advice. The goal of this show is to provide various points of view about GLP-1 Medications. The personal and professional opinion of the guests and their content does not necessarily reflect the opinion of Ana Reisdorf or GLP-1 Hub.
