Beta-hydroxybutyrate, the primary ketone your body produces, is turning out to be one of the most compelling molecules in longevity and healthspan science. It fuels your brain when glucose falls short. It influences gene expression. It signals your cells to burn fat more efficiently. And a single dose has been shown to improve cardiac output, ejection fraction, and stroke volume in patients with heart failure.
Dr. Latt Mansor grew up in Malaysia surrounded by chronic disease. His father died of a stroke when he was 17. His half-brother died of a heart attack at 43. His mother's side of the family carries decades of obesity and diabetes. That personal history took him from Oxford, where he studied the diabetic heart under low-oxygen conditions, to leading a $6 million Department of Defense contract on exogenous ketones and elite military performance. Now he has come full circle, using what peak-performance science has revealed to help build the case for prevention.
Dr. Mansor holds a DPhil from the University of Oxford and serves as Research Director at H.V.M.N., the company behind Ketone IQ.
In this conversation, we cover:
- What exogenous ketones actually are and how they differ from the endogenous ketones your body already makes
- How beta-hydroxybutyrate acts as a signaling molecule that binds directly to DNA and why a recent transcriptomics analysis showed it affected up to 300 genes
- The brain energy implications for women navigating perimenopause and menopause
- Exogenous ketones and GLP-1 receptor agonists: can they work together to protect lean mass and reduce brain fog during weight loss
- New unpublished appetite suppression data showing Ketone IQ's direct effects on GLP-1, ghrelin, and leptin
- Why Dr. Mansor calls it "the adaptive fuel" and what that means for how you use it
The research on exogenous ketones is still catching up to the biology. The long-term human data is incomplete. But the mechanistic rationale is compelling, the early clinical signals are hard to ignore, and this conversation will give you the scientific foundation to decide whether any of it belongs in your longevity supplement stack.
Connect with Dr. Latt Mansor:
Social media: @lattmansor
Website: ketoneiq.com
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