Dr. Max Gulhane (MD) is a practising family medicine physician and health-optimising physician with a passion for root-cause analysis of human chronic disease and longevity. We discuss the full solar spectrum and how ultraviolet, visible, blue, red and near-infrared light each affect human physiology, including the POMC pathway, nitric oxide and blood pressure, and the evidence on sunlight, skin cancer and the vitamin D paradox. We discuss how artificial light at night suppresses melatonin and disrupts the circadian control of DNA repair, cardiovascular health, and metabolism. For those interested in light and circadian health, Dr. Gulhane offers a grounded, mechanism-focused framework for aligning daily light exposure with human biology.
00:00 Intro 03:25 Dr. Max Gulhane 04:02 Dr. Gulhane's Love for Science and Medicine 09:01 What is Light? 12:52 Sunlight Broken Down as a Nutrient 14:02 Ultraviolet Light: Sunlight Is More Than Vitamin D 15:56 POMC 21:38 UVA/UVB on Cardiometabolic Health 24:40 Big Picture of UV Light 28:41 Sunlight, Skin Cancer, Dermatology Messaging, The Vitamin D Paradox 35:10 Blue Light, Artificial Light at Night (ALAN), Mechanisms 38:50 Sponsor: Daylight Computer 40:34 ALAN, Epidemiology, Cancer, Heart Disease 45:04 DNA Repair Mechanisms, Circadian Control 47:27 Melanopsin (OPN4), Blue Light, UV Susceptibility 53:25 Red, Infrared, Photobiomodulation, Metabolism 01:00:08 Blue Light, Metabolism, and the Built Environment 01:05:19 Photobiology of Atherosclerosis 01:10:11 Blue Light on Cardiovascular Function 01:12:25 Three M's of Circadian Health 01:18:43 Sunlight, Testosterone, and Reproductive Behavior 01:24:14 Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Social Media, Substack Newsletter
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