What is the new 2026 classification for acute pulmonary embolism? What is the respiratory modifier? What category encompasses normotensive shock? What is the difference between the PESI score, sPESI score, Hestia score, and CPES score? Should LMWH or unfractionated heparin be used for initial parenteral anticoagulation for PE? What anticoagulation agent for PE is recommended in patients with antiphospholipid syndrome, chronic kidney disease, brain tumors, or pregnancy? In which patients is systemic lysis, catheter-directed thrombolysis, mechanical thrombectomy, or surgery appropriate? How should clot-in-transit be managed? Is there a role for pulmonary vasodilators? How should vasopressors be dosed in acute PE? How is CTEPD different from CTEPH? How long should anticoagulation be continued after PE? Watch for answers to these key questions in this "deep dive" of the 2026 AHA/ACC/ACCP/ACEP/CHEST/SCAI/SHM/SIR/SVM/SVN Guideline for the Evaluation and Management of Acute Pulmonary Embolism in Adults — the first-ever dedicated AHA/ACC guideline on acute PE.This episode also available on YouTube: https://youtu.be/rE-I4Jwq1UA
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