Today’s episode is brought to you by Strata. Modernize your IAM with Identity Orchestration. Visit https://strata.io/firstprinciples to learn more!
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Episode 15: Bryan Johnson spends $2m/year to not die. But this is more than just a health craze — it’s the birth of a new, secular religious movement. Here’s what Bryan believes.
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(00:00) - Introduction (01:13) - Zeroth Principles Thinking: Going Beyond First Principles (04:05) - The Journey to "Don't Die": Bryan's Thought Experiments and Realizations (07:28) - Is "Don't Die" a Religion? Examining the Parallels (10:40) - Bryan's Roles in "Don't Die": Philosopher, Embodiment, Message Bearer (13:05) - Sponsor Break (14:08) - Quantifying Death: Introducing "Die Scores" for Behaviors and Choices (17:03) - What is Death and What is Aging? A First Principles Perspective (19:40) - Measuring Biological Age: Organ by Organ Analysis of Bryan's Body (23:48) - The Penis as a Marker of Overall Health and Vitality (26:33) - Epigenetic Clocks and the Pace of Aging Calculated Tests (30:18) - Bryan's Experience with Follistatin Gene Therapy (32:25) - Kernel: Building a Mass Market Brain Interface with Time-Domain FNIRS (36:48) - The Power Law Interventions: Identifying the Most Effective Longevity Levers (39:22) - Assembling a Team of Scientific Misfits to Tackle Aging (41:05) - Dreaming Up Ideas: Bryan's Nocturnal Creativity (42:15) - Telomeres and the Risks of Telomerase Gene Therapy (44:38) - Reflections on the Challenges of Commercializing Deep Tech (46:29) - Conclusion: Banding Together to Build an Amazing Future
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